SGL — 001 / Cargo

The miRNA reference set

Two cargo tiers, read side by side: the replicated MSC-EV workhorse set, and the pluripotency entries proposed for rejuvenation. Switch to the pathway view to see where they converge. 4 of 24 entries are marked ± — direction of effect reverses by context.

§ — Pathway convergence

Every entry linked to the pathways it targets. The cell-cycle / senescence node draws almost entirely from the pluripotency tier — the convergence the chassis is built on.

let-7 ±miR-100-5pmiR-125b ±miR-126miR-132miR-133bmiR-146a ±miR-17-92 ±miR-181miR-19amiR-21miR-210miR-214-3pmiR-22-3pmiR-221/222miR-24miR-29miR-410miR-486-5pmiR-290-295miR-296-5pmiR-302miR-371-373miR-9-5pPTEN/PI3K-Akt9Cell-cycle / senescence8NF-κB2TGF-β/SMAD2Wnt/β-catenin2hypoxia/HIF axis1
mscpluripotent
Group by

§ 01 — msc

19 of 19

§ 02 — pluripotent

5 of 5